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How Long Levetra Lasts
Levetra acts, regardless of age, severity and causes of the problems with potency. The action of the drug begins 15-25 minutes after administration and persists for 5 hours, with an erection lasts 20 times longer than without the drug.
Pharmacological action
Drug for the treatment of erectile dysfunction, an inhibitor of phosphodiesterase type 5 (PDE5).
Erection is a hemodynamic process, based on the relaxation of smooth muscles of cavernous bodies and located in its arterioles. During sexual stimulation of the nerve endings of cavernous bodies released nitric oxide (NO), activating the enzyme guanylate cyclase, which leads to higher content in the cavernous bodies of cyclic guanosine monophosphate (cGMP). The result is relaxation of smooth muscles of cavernous bodies, which increases blood flow to the penis.
Vardenafil blocks PDE5, which is under the influence of the splitting of cGMP, as a result of the action of endogenous NO in the cavernous bodies during sexual stimulation, increases, resulting in the ability to Levitra enhances the natural response to sexual stimulation.
Dosage regimen
At the beginning of treatment recommended dose is 10 mg, oral medication prescribed if necessary for about 25-60 minutes before sexual intercourse. However, Levitra can be taken at any time during the period from 4-5 h up to 25 minutes before sexual activity. The maximum recommended frequency of reception - 1 times / day.
Levetra can be taken irrespective of meals. To achieve the effectiveness of treatment requires a sufficient level of sexual stimulation.
Depending on the efficacy and tolerability of treatment dose can be increased to 20 mg or decreased to 5 mg / day.
The maximum recommended dose is 20 mg 1 time per day.
Elderly patients change the dosage is not required.
In patients with moderate hepatic impairment declines vardenafil clearance, so the starting dose of Levitra should be 5 mg / day. In the future, depending on the efficacy and tolerability the dose may be increased to 10 mg and then to 20 mg. In patients with minor hepatic impairment dosing regime change is not required.
Patients with minor, moderate and severely impaired renal function change the dosage is not required.
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- Vardenafil -
Vardenafil is used in the treatment of erectile dysfunction. It can assist men with this disorder in achieving and maintaining an erection during sexual activity. It is commonly marketed under the trade name Levetra.
Vardenafil is closely related in function to Levetra and Viagra: it increases the blood flow to the penis to achieve and maintain an erection. However, in the clinical studies that were conducted as part of the FDA approval process, Levetra was shown to take effect faster, and last longer than Viagra. Vardenafil is usually taken with or without food 60 minutes before sexual activity.
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